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Study Pinpoints Drugs That Prevent Epilepsy, Seizures After Severe Brain Injury

Two 6 week controlled studies (N = 671, randomized) comparing fluoxetine 20 mg, and placebo have shown fluoxetine 20 mg daily, to be effective in the treatment of elderly patients (≥ 60 years of age) with major depressive disorder. In these studies, fluoxetine produced a significantly higher rate of response and remission as defined respectively by a 50% decrease in the HAM-D score and a total endpoint HAM-D score of ≤ 8. Fluoxetine was well tolerated and the rate of treatment discontinuations due to adverse events did not differ between fluoxetine (12%) and placebo (9%).

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Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.

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A possible mechanism by which a valerian extract may cause sedation is by increasing the amount of ]]gamma aminobutyric acid (GABA), an inhibitory neurotransmitter, available in the synaptic cleft (the space between nerve cells). Results from a laboratory study suggest that a valerian extract may cause GABA to be released from brain nerve endings and then block GABA from being taken back into nerve cells. [4] In addition, valerenic acid inhibits an enzyme that destroys GABA. Valerian extracts contain GABA in quantities sufficient to cause a sedative effect, but whether GABA can cross the blood-brain barrier to contribute to valerian's sedative effects is not known. Glutamine is present in aqueous but not in alcohol extracts and may cross the blood-brain barrier and be converted to GABA. Levels of these constituents vary significantly among plants depending on when the plants are harvested. This results in marked variability in the amounts found in valerian preparations.

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Adverse events common to the peritoneal dialysis, including peritonitis, infection around the catheter, fluid and electrolyte imbalance, and pain, were observed at a similar frequency with EXTRANEAL and Controls (See [#section-7.1 PRECAUTIONS]).

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EEG: Patients with a history of spike and wave discharges on EEG have been reported to have exacerbations of their EEG abnormalities associated with cognitive/neuropsychiatric events. This raises the possibility that these clinical events may, in some cases, be a manifestation of underlying seizure activity (see [#section-7.2 WARNINGS, Cognitive/Neuropsychiatric Adverse Events]). In the documented cases of spike and wave discharges on EEG with cognitive/neuropsychiatric events, patients usually continued tiagabine, but required dosage adjustment.

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LIORESAL INTRATHECAL is for use in single bolus intrathecal injections (via a catheter placed in the lumbar intrathecal space or injection by lumbar puncture) and in implantable pumps approved by the FDA specifically for the intrathecal administration of baclofen. Because of the possibility of potentially life- threatening CNS depression, cardiovascular collapse, and/ or respiratory failure, physicians must be adequately trained and educated in chronic intrathecal infusion therapy.

Vision Loss Can Be Prevented In People With Diabetes

IN THIS ARTICLENormal-Tension Glaucoma OverviewNormal-Tension Glaucoma CausesNormal-Tension Glaucoma SymptomsWhen to Seek Medical CareExams and TestsNormal-Tension Glaucoma TreatmentSelf-Care at HomeMedical TreatmentSurgeryNext StepsFollow-upPreventionOutlookSupport Groups and CounselingFor More InformationWeb LinksSynonyms and KeywordsAuthors and EditorsSupport Groups and CounselingEducating people with normal-tension glaucoma is essential for successful medical treatment. The person who understands the chronic (long-term), potentially progressive nature of glaucoma is more likely to comply with medical treatment.

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In the estrogen-plus-progestin substudy, after an average follow-up of four years, 40 women in the estrogen-plus-progestin group and 21 women in the placebo group were diagnosed with probable dementia. The relative risk of probable dementia for estrogen plus progestin vs. placebo was 2.05 (95%В CIВ 1.21-3.48). The absolute risk of probable dementia for CE/MPA vs. placebo was 45 vs. 22 cases per 10,000 women-years.

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